July 1, 2015 at 11:03 pm #7774hydrarktParticipant
I think I was exposed to HSV (not sure which type) 1.5 years ago. I say this, as I had a small outbreak of herpes looking blisters on my penis. Approximately 3 months later, I had an HSV IGG blood test: HSV-2= negative. I was positive for HSV-1=positive. But I’ve had oral cold sores since a child, so I figured that was it.
Four months later, I had itching but no blisters in my groin. I went for another full IGG blood test. Same results:
HSV-2=negative, HSV-1= positive.
Four months later, more itching.. thought maybe fungal from steam bath… no tests
Five months later, small herpes looking blisters, no pain at all. I went got them swabbed the same day: on the phone, the nurse said culture reacted to HSV-2. I started with 500 mg Valtrex per day… 2 weeks later, I took another IGG blood test for HSV-2 only = negative.
HSV 2 IGG, TYPE SPECIFIC AB HERPESELECT
HSV 2 IGG TYPE SPECIFIC AB <0.90 01
So now I’m confused. 3 IGG HSV-2 negatives and one swab positive for HSV-2!!!
I know there are false positive and negatives. And I’ve heard that the swab test is the “gold standard.” But 3 false negatives on bloods seems unlikely.
Any ideas what could be going on?
- This topic was modified 7 years, 7 months ago by hydrarkt.
July 3, 2015 at 3:02 pm #7816Terri WarrenKeymaster
Hmmm. It looks to me like the antibody test missed the HSV 2 infection. Our most recent study of the sensitivity of the screening test confirms the package insert on this one – it misses only about 3 out of 100 cases. Yours looks like it is one. A positive AND typed swab from a recurrent lesion (four thing here: lesion, recurrent nature of the lesion, positive swab, and the ability to type it) suggests that the swab test is correct, not the antibody test. You could do a western blot to see how that turns out.
In my experience, once the antibody screening test misses an infection ,it will miss it every time (or most every time).
July 6, 2015 at 6:44 am #7914hydrarktParticipant
Ok. Thanks. Where can I get the Western Blot done? I live in Boston.
July 6, 2015 at 3:11 pm #7926Terri WarrenKeymaster
Our clinic can order the western blot for you easily, to be drawn at a lab near where you live in Boston. It will be shipped to the University of Washington for you. You need to call the clinic to make a phone consultation appointment at which time you and I will discuss the testing and arrange it for you.
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