July 17, 2019 at 8:35 am #44100Tm3344Participant
I have HSV-1. For the past year I have been taking Valtrex daily (1 gram once a day) because I was having more frequent breakouts due to stress.
I have been HSV-2 negative on prior tests and never had any outbreak.
The person I was dating is positive for HSV-2 and was also on daily Valtrex. We used to only have unprotected sex.
I recently had another blood test done. It was labcorp IgG specific immunoblot. The test came back positive for both 1 and 2.
This was back in May. I had another test performed this month because I wanted a test with the index value like the previous tests I’ve had. This test came back negative. This was another IgG test, CLIA.
My question: is this possible? Do you believe the immunoblot test to be a false positive? I read that these seem to be even more accurate than the other test I had so I am wondering if it’s more likely the test this month was a false negative.
I was concerned maybe the second test was a false negative because of the Valtrex. My doctor feels this is unlikely stating that if it came up positive on the other test, the Valtrex wouldn’t have lowered antibody levels that were already present and should have still triggered a positive result. So she feels as though I am negative
I stopped the Valtrex for now because I’m considering testing again in a few months. But if I don’t have an outbreak, we are not sure if it is worth it. Since stopping I have now been getting sharp pains around my penis. But still no visible outbreak. Hoping it’s just in my mind.
Thanks in advance for the help.
July 23, 2019 at 11:52 am #44342Terri WarrenKeymaster
The immunoblot is difficult to read and it is subjective as well – is there a bar present or not? Sometimes there is just a shadow present which COULD represent a false positive – who knows? We stopped doing it at the clinic because it was just too damn subjective. I would lean more toward it being a false positive.
How long after your first HSV 1 outbreak did you start daily suppression? How many outbreaks were you having? How were you diagnosed with HSV 1?
July 23, 2019 at 2:02 pm #44388Tm3344Participant
No bar present.
I have had HSV 1 since I was a little kid, (34 yrs old now). I had just started taking the Valtrex because I was getting pretty bad outbreaks a few times a year on my lip which I believe is due to extreme stress. Usually I would only get an outbreak maybe once every few years and it was mild. I was diagnosed by visual inspection of the sore and a positive HSV 1 IgG test.
So I am just wondering what the chances are that an immunoblot IgG would show positive for HSV 2 but then an IgG with index values would come back completely negative 2 months later. Wasn’t sure if the Valtrex could cause this. Pretty confusing. My doctor feels that if the first test was indeed positive then the Valtrex wouldn’t have had an impact on the second test….thoughts?
July 29, 2019 at 6:04 am #44601Terri WarrenKeymaster
I was referring to the bar that presents itself on the test indicating a positive. Now sure what you are referring to when you say no bar.
The Valtrex is NOT impacting the results of the testing in your situation.
My guess is, given the negative IgG, that you are NOT infected and the immunoblot call is a false positive but that’s a guess.
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