February 23, 2019 at 11:57 am #30948
I am a 62 year old male in W. Washington, asymptomatic as far as I can tell. Never have had a typical cold sore, though both parents experienced outbreaks.
Recently had what I believed to be a pimple below my lip. Had a cone shape & center core & developed apparent pus. Presented & healed in 4 days. While scabbed doctor DNA tested 1/9/2019: “HSV1, HSV2 & VZV DNA NOT detected by NAAT”
11/13/97 Western Blot POSITIVE for HSV-1 negative for 2
1/5/1998 U of W test negative for 1 and 2
2/9/1998 Paclab POSITIVE for 1, negative for 2
7/19/1999 Paclab HSV-1 Igg .16, HSV-2 Igg .15. IgM .49
10/26/1999 Paclab HSV-1 Igg .18, HSV-2 Igg .29. IgM .33
2/16/2010 Quest HerpesSelect <.90 for both
8/6/2010 Quest HerpesSelect <.90 for both
4/23/2012 Quest HerpesSelect <.90 for both
3/6/2013 Quest HerpesSelect HSV-1 Igg .94 HIGH, verified with repeat test. <.90 HSV-2
7/14/2017 LabCorp <.91 for both
9/21/2017 Providence (PAML) both negative HSV-1 <.01, HSV-2 .0938
7/20/2018 Kaiser HSV-1 <.01, HSV-2 .213
1/28/2019 LabCorp HSV-1 <.91, HSV-2 2.07 HIGH with positive/abnormal supp. test
2/1/2019 Kaiser (was supposed to be Western Blot) HSV-2 1.88 HIGH
2/11/2019 Western Blot 1 and 2 INDETERMINATE
History in past years included periods of increased risk behavior, especially in first half of 2018. Past ten years had 1 incident of unprotected vaginal sex in first half of 2018. In that period had multiple unprotected oral sex encounters.
U of W virology is recommending retesting with Western Blot in 3 months for paired serology testing. I will do so. I’m curious about a reference I found to ABVIC, a supposedly improved serological test. Your name connected to the work in 2016.
In the meantime, I am wondering if you might have any observations based on the test history, or further recommendations, & based on the preceding, would you recommend that I consider myself positive for HSV-2 until proved otherwise.
February 23, 2019 at 3:54 pm #30970
Did you do the western blot through me? If yes, I can ask the lab to look at it again in light of your previous positive HSV 1. The HSV 1 testing through commercial labs is just pathetic and unclear unless the value is > than 3. Your hSV 2 has been in the low positive range and you are likely NOT Infected though the second blot in 3 months should shed light on the true HSV 2 status. I would advise no sexual contact in the meanwhile or your baseline date will have to start all over again.
ABVIC is not a test that has been verified in any way and the creator has died and was in deep trouble with the FDA for unprofessional behavior.
February 24, 2019 at 11:02 am #30981
Thanks for your reply, Terri.
I did not do the Western Blot through you, but would be willing to consider doing a consult with you if that would enable you to request a further look at the test at the U of W.
I understand your recommendation on abstention for the next three months, but I am curious about something. Obviously, an activity introduces the potential for new exposure, but if the three month wait before doing another test is to allow adequate time for for the process of seroconversion to occur, would new exposure have an affect on that? Not trying to downplay the positive aspect of a test result that one can have confidence in, but curious nonetheless.
Appreciate the feedback on ABVIC. Unfortunate there are people out there that engage in that sort of activity.
February 25, 2019 at 7:15 am #31043
You don’t have to do the blot with me, but I’m quite sure they no longer have the blots available for 1997, now that I think about the dates more carefully. You could ask the provider that ordered the test for you to alert the lab to a previous positive blot in 1997 and ask them to re-read the blot done recently.
The recommendation about abstinence is to not complicate the situation with a potentially NEW infection from a NEW partner. It is also a recommendation to allow for a late seroconversion.
April 18, 2019 at 10:31 am #34582
Good morning Terri:
This may be the last post on this thread, but I thought I would bring you and the forum up to date. Second Western Blot has been completed as shown below:
11/13/97 – Western Blot POSITIVE for HSV-1 negative for 2
1/5/1998 – U of W test negative for 1 and 2
2/9/1998 – Paclab POSITIVE for 1, negative for 2
7/19/1999 – Paclab HSV-1 Igg .16, HSV-2 Igg .15. IgM .49
10/26/1999 – Paclab HSV-1 Igg .18, HSV-2 Igg .29. IgM .33
2/16/2010 – Quest HerpesSelect <.90 for both
8/6/2010 – Quest HerpesSelect <.90 for both
4/23/2012 – Quest HerpesSelect <.90 for both
3/6/2013 – Quest HerpesSelect HSV-1 Igg .94 HIGH, verified with repeat test. <.90 HSV-2
7/14/2017 – LabCorp <.91 for both
9/21/2017 – Providence (PAML) both negative HSV-1 <.01, HSV-2 .0938
7/20/2018 – Kaiser HSV-1 <.01, HSV-2 .213
1/28/2019 – LabCorp HSV-1 <.91, HSV-2 2.07 HIGH with positive/abnormal supp. test
2/1/2019 – Kaiser (was supposed to be Western Blot) HSV-2 1.88 HIGH
2/11/2019 – Western Blot 1 and 2 INDETERMINATE
4/8/2019 – LabCorp HSV-1 <.91, HSV-2 1.54 HIGH. Supplemental test was
4/5/2019- Western Blot 1 and 2 POSITIVE, paired with test from 2/11/2019
As you will see, out of a combination of impatience and curiosity, I did an additional LabCorp test on 4/8. Shared the results of that test with the virology clinic and got this in a response:
“It looks like you’re one of the people who will always have a low-positive result on the IgG. We believe it may be due to cross-reaction with an immune response to a closely-related virus, perhaps another virus in the herpes family of viruses. Let’s see what this final Western blot results look like and go from there!”
Any thoughts you have will be appreciated.
April 22, 2019 at 11:50 am #34702
The western blot obviously overrules the IgG test. Is there a possibility that you became infected early in 2019 or late in 2018?
Did UW change the reading for the first western blot from indeterminate to positive or did they leave that alone?
April 22, 2019 at 1:25 pm #34715
It’s possible, but I think unlikely. Some sexual interaction but no intercourse or oral sex. UW changed the first to positive for both 1 and 2 as well.
The falling levels on the IgG test interests me. I would be happy to do another subscription and post my question there if you like.
April 22, 2019 at 2:45 pm #34733
Bingo. I thought that’s what might have happened here. The IgG levels tell you nothing whatsoever of interest. This is very normal variation. What matters it the positive western blot.
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