July 23, 2019 at 3:27 pm #44390
I appreciate your website.
My story is this, I had a severe outbreak in 2016 with classic lesions on my genitalia. Had a severe flu like syndrome. This occurred about three weeks after sex with someone. Went to clinic and they did the PCR test which was negative. Started Valtrex. Eventually took IGG test which was negative. I then stopped the Valtrex and two or three months later had another negative IGG test. Then went back on Valtrex but stopped again and then in 2017 after being off Valtrex for 2 months did the Univ of Washington WB, which was negative. Still not convinced, I redid the western blot in 2018 and it was again negative. I never had lesions again but I do get burning and tingling once or twice a year and possibly some redness but no lesions.
I don’t want to infect anyone and I really thought I had herpes lesions in 2016. They were bad for three weeks.
My questions are; should I redo the WB or is it just going to negative again? Should I stop worrying about this and risk having sex again?
Could I have a false negative HSV1? I read here that a false negative HSV2 is very rare. If I have it I would just rather know.
July 29, 2019 at 6:08 am #44602
This is a bit of a complicated situation. Your description of your initial lesion presentation does sound herpetic, I would agree. The PCR could have been falsely negative because you tested so late in the outbreak (if it was an outbreak at all).
How long have you been off Valtrex now? I would not suggest that you test now again with the blot unless you have been off of Valtrex for at least three months.
The western blot is 96% sensitive for HSV 1, not as good as HSV 2 but still way better than the 70% sensitivity of the IgG test. If this was HSV 1 genitally, you would be shedding on about 7 days out of the year.
Two things: you could re-d0 the blot and 2) swab anything that looks suspicious
August 27, 2019 at 4:00 pm #48470
So I did the western blot for the third time. I have been off valtrex for around five to six months. The test came back again negative for both. My belief is that I either do not have herpes or I have hsv1 given that the WB is very reliable for type 2. Hsv1 would also fit with the fact that I never have broken lesions but very sensitive or even burning skin on the scrotum and penis about twice a year. In fact, I had a recent stressful even with the death of my pet and that brought it out. I also see no point in repeating these tests. What are your thoughts on my thoughts. Thanks
August 29, 2019 at 8:11 am #48729
I think you should count on the results of the blot and not do any more testing.
August 29, 2019 at 10:44 am #48743
I agree in no more testing since it’s not going to change. For my final question, how often have you seen people with negative WB but positive HSV1?
September 6, 2019 at 6:43 am #49008
Positive HSV 1 swab you mean, from a lesion? I’ve not seen that personally.
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