August 24, 2021 at 1:36 am #74664
i am a 29 yr old Male.
Regarding my herpes issues, i have always had cold sores from a tender age and i once had chicken pox, however i noticed little bumps on my penis after masturbating over 5 times in a day last year February 2020, this happened after breaking up with my ex.
I only notice this little tiny small bumps tends to flare up only when i masturbate and they heal just immediately without any open ulcer like the pictures of what herpes looks like in both male and female ( shallow/red). The bumps doesn’t flare up if i don’t masturbation
i did blood test iGG which came back as HSV 1 – 35.15 ( i had known this already due to my past history of cold sores / fever blisters when i was much younger) and HSV 2 was Low positive ( weak positive ) .
i went to a second clinic and i had another blood test done. my HSV 1 was High positive as confirmed from the previous and the HSV 2 was Negative
Please note that this tests were done just exactly 1 YEAR and over 5 months after the first flare up which i believe my antibody should be mature enough to tell if its positive or not
i went to the 3rd clinic and had the blister swabbed and it was confirmed positive for HSV 2. i never asked for the value. i told the doctor my igg blood at 2 different clinics was negative and low positive and she was confused. i said my body should have developed antibodies in that huge time frame.
To recap :
1st test – HSV 1 – 45.1 HSV 2 – Low/ weak positive
2nd Test – HSV 1- 47.9 HSV 2 – Negative.
3rd Test – SWAB TEST FOR HSV 2 – Positive ( i didn’t ask for the value )
Please Terri from your 35 years of experience,
1) is it possible to get a negative for HSV 2 for igg blood test and a positive for HSV 2 swab test
2) is it possible that due to my high HSV 1, it cross-reacted to give a possible HSV 2 for the swab test ?
Not forgetting the fact that its over 1yr 5 months
i really need your help on this Terri.
Thanks in advance
August 30, 2021 at 4:35 pm #74706Terri WarrenKeymaster
Ugh. a Very complicated case.
If I were in your situation, I would get a western blot for greater clarity.
There are very few false-positive results on swab tests but I have seen a couple of false-positive and a few lesions that have been mistyped.
It is certainly positive to have HSV 2 and get a false negative HSV 2 antibody test. The IgG test misses 8% of HSV 2 infections compared to the gold standard western blot
Your history of oral HSV 1 would not cause a false positive on a swab test of a genital lesion
But what you had swabbed was a bump that lasts a single day?
September 9, 2021 at 10:32 am #74826
Sorry for the late response Terri, what i had swabbed was not a bump that lasts a single day. i think i did the swabbing 2 days after noticing the bump. i mistakenly used my finger to prick it tho. it was healing already before i went for the swab test.
i haven’t had any outbreak since the last time.
My Question will be :
1) Do you think i should still go ahead and get the western blot ?
2) is it possible to have a false Negative HSV 2 IGG blood test after 1 year and 8 months ?
September 13, 2021 at 8:34 am #74858Terri WarrenKeymaster
The blot would give you greater clarity, no question
And yes, it is possible to have a false negative IgG test after having the infection for 1 year and 8 months. The IgG test misses 8% of HSV 2 infections, compared to the western blot.
September 13, 2021 at 10:31 am #74870
Thank you once again Terri.
1) When will you open up a new slot for September so i can order the western blot ?
2) I took my time to read posts and responses from you to others and i could see where you clearly said that Antibodies against herpes tends to develop in the body within 16 weeks and at most 4 – 6 months for IgG Tests and that there should be a clearer picture to show if the person is infected or not even tho western blot doesn’t miss .
In my case, it has been 1 year and 8 months, my value is:
H.S.V.II (IgG) 0.709 Index
Are you saying this value above can be false Negative after 1 year and 8 months ?
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