October 8, 2018 at 9:47 am #27283
I am a 38yo married male. I have had several partners beginning March 2018, with the last contact being ~ early/mid July.
Up until Aug 18 2018, I had never taken any STD test before. I did the standard 10-test STD panel. Tests came back negative except for HSV-2, which I got an index of 13.30. This was devastating news, and 12 days later (On Aug 30) I had another HSV2 IgG test done, index 16.90
After this second test, I accepted the reality that I have HSV-2. However, reading about the western blot test, I had my blood drawn for the WB on Sept 18. Results were received ~ 2 weeks later, Negative for HSV-1, and HSV-2 “Indeterminate”
The day my blood was drawn for WB, I requested daily valtrex, to reduce transmission chance to my wife. After getting WB results, and finding this forum, I realized valtrex interferes with seroconversion and immediately stopped taking it. It was for 2 weeks that I took it, from Sept 18 to the beginning of Oct. My blood was drawn for WB Sept 18, before I took the first pill.
My wife has tested herself several times since this all began, and as of last week tested negative (igG). At no time have I seen anything worrisome “down there”, i.e. I have never personally had any visible symptoms.
1. Do I have any reason to be even cautiously optimistic that I don’t actually have it?
2. I realize it takes 3-4 months for most people to seroconvert, and I only now (after finding your forum) realize I took the WB too early. But still, considering my IgG was already so high, already at 16.90 on Aug 30, 19 days before my WB blood sample was drawn… do you think it’s odd that I got an Indeterminate?
3. When do you recommend I get another WB done, considering my timeframe as noted above, and considering I took daily valtrex for 2 weeks? Cost is not an issue, and if I am HSV2 positive I’d rather know sooner than later. This waiting and not knowing for certain is difficult on both me, my wife, and our marriage relationship.
October 8, 2018 at 11:12 am #27293
Your situation is completely atypical.
First, the medication that you took had nothing to do with the first blood draw which I think you know and if you stop now, it should not interfere with future testing. When was the last time you had sex with anyone other than your wife? You seem to already know that you need to wait three months to get an accurate test result. The recommendation from the University of Washington is normally to wait three months, get the blot, if indeterminate, do the test in another three months. But in your case, it sounds like you tested too early in the first place. So my recommendation now would be that you wait a total of six months from the last encounter with someone other than your wife before retesting. If you are indeterminate again, it is likely that you are uninfected. The guidance from the University of Washington is two indeterminates three months apart should be interpreted as a negative.
October 8, 2018 at 11:17 am #27295
I don’t know the exact date (sex with anyone other than the wife), but it was Early/Mid July. So, 3 months ago. Thanks for the advice, I will remain in limbo for a few months, then get another blot done. I will report back and let you know what result I get.
I remember reading something about when re-testing, to let UW know it’s a second test and to compare the results of the first test to the 2nd? Is this something I should do, or just have a 2nd blot done and say nothing to them about having tested indeterminate previously?
October 8, 2018 at 3:21 pm #27299
Yes, you can do it either way. Running both samples together is more expensive but it is slightly more accurate then comparing the two black side-by-side.
November 4, 2018 at 10:15 am #27768
A month has gone by since my last post. I will be doing another WB when the time is right, in the meantime I am worrying about this quite a lot.
I had another igg test done, just for curiosity’s sake. It was 16 again. So my igg levels have remained pretty much level for the past few months. Is this consistent with what you usually see in a relatively new infection, or just super strange? Since my WB was indeterminate, I assume I am either uninfected, or in the process of seroconversion – but if I actually got infected early July, is it even possible my igg levels could have been as high as they were by just the next month?
I guess my question is, are my really high and stable igg values consistent with a relatively new infection? One thing I was not able to find from an internet search is what igg levels HSV2+ individuals usually get in their testing, most of the nummbers I have seen are a lot lower than mine.
November 4, 2018 at 8:26 pm #27774
With an index value of 16, I do NOT think you should assume you are uninfected. This is confusing but your IgG is high enough that it is just not making sense to me that you have an indeterminate right now. The high index value is not consistent with new infection, no. The index values do vary with new infection but they are usually much lower than this with new infection.
Have you taken antiviral medicines?
November 5, 2018 at 8:38 am #27784
I am definitely not assuming I am uninfected – I am assuming the opposite. But have never had any symptoms whatsoever… So it’s just a waiting game until I get another WB done, I guess.
Reread my 1st post to get a better feel for the timeline. I did take valtrex for 2 weeks, but stopped as soon as I came across your forum. I didn’t take it until after my blood was drawn for WB, though. So my igg was 13.3 on Aug 18, 16.9 on Aug 30, and my sample was taken for WB on Sept 18 and tested indeterminate. Igg as of a week ago, oct 25, is 16.
November 5, 2018 at 8:52 am #27785
Also, just curious… what are “typical” IgG values for a long term infection? Are they usually lower than 16-17 as well? This whole thing is kinda weird, for sure!
November 12, 2018 at 8:22 am #27951
November 12, 2018 at 8:38 am #27955
OK, I just renewed, please reply to the above posts. Thanks for your help!
November 12, 2018 at 9:43 am #27979
Generally speaking, the majority of people who test at an index value of greater than 3.5 are infected with HSV 2. There are some exceptions– I tested a person with Western blot who have an index value on the IgG of 12 and she was negative by Western blot. The University of Washington had a patient who tested with an index value of 14 who tested negative by Western blot
Did you do your Western blot with me? If yes, I can ask the lab to look at it and review the indeterminate. If not, cannot do that. Generally, the guidance on how to interpret a indeterminate result is if you get two indeterminate results three months apart, you should consider yourself negative. With this high-value, I definitely think it would be worth asking the lab to look at these again if that happens. What lab did your IgG testing?
November 12, 2018 at 9:48 am #27981
Yeah, we’ll just have to see… I will get another WB done. No I didn’t do the first with you, I did it with my local doctor.
OK sounds good. IgG test performing lab was Labcorp Phoenix.
November 12, 2018 at 9:59 am #27986
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