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Hello first of like to thank you for all you
Do. I was exposed to hsv2 in mid October and I had us tested after I noticed a small bump that the dermatologist said was malluscum bump. I’ve always had hsv1 so my results came back negative for everything and high antibodies for hsv1 (which I expected) her results came back positive with hsv1 and 2. Hsv2 was high antibodies. After the dermatologist froze off the malluscum a few days later I noticed a burning sensation on the midline of median raphe. The midline below the shaft and few inches down from the malluscum bump. I got relief when I would stand up or walk or as I sleep. When I sit this will persist. I don’t feel any tingles or anything and I’ve tested 8 wks post exposure and got a negative result.
I know it’s still early yet but having hsv1 I read can slow down seroconversion for hsv2. Is this true?
Without antibodies wouldn’t one expect lesions and blisters or is hsv1 high antibodies of 30+ help In fighting off hsv2?
The past 2 months I’ve lost sleep and have been stressed and anxiety is through the roof. I would expect the blisters to come full force by now.
Could it be the anxiety and stress to give me this burning feeling, I urinate with no issues as the burning feeling is on the midline raphe on bottom of penis shaft just before base and scrotum. If it was hsv2 related I shouldn’t feel relief as I stand again it only bothers me as I sit. I plan to retest at 3 and 4 months. I was just wondering with no present antibodies after 8 wks wouldn’t you think I’d of seen blisters by now as much as I’ve been paranoid. Or is hsv1 antibodies helping to keep blisters away. I don’t feel tingles or nothing and I’d be a little more satisfied with the test results had I not felt the burning sensation a month after exposure. Even if this was from friction could it show up at a later date. I haven’t been sexual active sinse mid October. Not even on my mind these days until I’m certain.I appreciate yourinput doc and thanku -
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Infection with HSV 2 here seems very unlikely to me with your negative antibody tests so far and no blistering on the penis. The fact that you get relief by standing suggests some sort of possible prostate issue. You could certainly do the blot but only if you are uncomfortable wit the 92% certainty offered by the IgG test. The 99% quoted in the test literature is the percent of infection picked up in people KNOW to have HSV 2 because they had positive lesion swabs. That is different than the percentage our study obtain when we were looking simple at people who requested screening for herpes. Do you see the different in the populations?
Terri
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Having HSV 1 can slow down HSV 2 antibody development by a week or two. Yes, people who have HSV 1 and acquire HSV 2 are likely to have more moderate symptoms than someone who does not have HSV 1. So a dermatologist told you it was molluscum? And you don’t think so?
I don’t think you need to wait 16-20 weeks to test further – are you doing the western blot of another IgG? The western blot is a better test.This is your final post on this subscription. If you have more questions, feel free to renew.
Terri
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I think testing at 15 weeks should be as definitive as the IgG test gets. HSV 2 does not cause burning for two months, no. I don’t believe it will be helpful to wait longer. The IgG test, when someone has waiting long enough to test, picks up 92% of HSV 2 and 70% of HSV 1, compared to the gold standard western blot.
Terri
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14 weeks is plenty of time to wait to be tested and no, smoking has no impact on testing. We apparently talked this week – will await test results.
Terri
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I see that you have paid for 6 posts, but not 12. did we talk last tuesday? If yes, please post your initials so I can look up your payments
Terri
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Yes, you can trust the negative blot if negative at 17 weeks out, even if you have HSV 1. The University of Washington actually changed the wait time from 16 to 12 weeks, even if a person has HSV 1. Your idea about the infection hiding in the nerve is not accurate. Just wait and see what the blot says, OK?
Terri
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The western blot picks up FAR more antibody than the IgG test. The IgG test looks for only one protein associated with HSV while the western blot looks for ALL the proteins associated with the HSV antaibody
The IgG can be positive sooner than the western blot, for the very reason described above.
The time you waited is way more than enough.
Molluscum is not normal for anyone.You need to let this go now!
Terri
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1. Let’s say 20 wks cause I’m going from last encounter. Does it sound promising and can I trust these results
Very promising, yes
2. I hace the wb kit and still plan on doing it in mid April closer to 6 months because I read it’s 99% at that point. Just curious about how it works. With neg igG will it still detect the 15 or so other antigens or does it go off the igG antibodies meaning if igG is negative wb would be negative. Or does the wb look for something diff then igG proteins, other antigens that deal with h2?
The western blot looks for all the proteins including the gG that the IgG looks for
3.I was told by my Dr if I have h1 antibodies it will fight off hsv2 for awhile untill hsv2 antibodies appear. That’s why it can take 6 months. Is this true? He honestly wasn’t to educated in this area as there was alot of misinformation. Why would people take that long anyway just curious if I’m healthy enough of think I’d have a borderline +by now.
I don’t agree with that. We do know that a person with HSV 1 takes a little longer to become positive for HSV 2 when one becomes infected but perhaps only a couple of weeks
4How fast does antibodies appear in an infected person? Do they sky rocket passed the .9 Mark or slowly build up upon infection and not an outbreak.
It could appear as easly as 7-10 days at a low level.
5is there a such thing as a small strain of the virus that slowly grows in your system or it doesnt work like rhat u either have it or u dont
No
I can deal with it but I’ll go nuts if I was to infect this innocent girl. She’s never been touched and in my culture it wouldn’t be a good thing.Terri
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it looks for all the proteins including the gG proteint, es
And yes, the IgG could be positive as soon as 7-10 days
The IgG is looking for a specific protein, a single one that is different between HSV 1 and 2. And that protein comes up pretty quickly in antibody development. So that’s why the IgG test can be positive sooner than the western blot because for the blot to be considered positive, at least four protein bands must be present.You are overthinking this a lot. Please stop reading on the internet.
A low positive at a later date means NOTHING unless confirmed by the blot.Terri
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That’s not how this works. The immune system recognizes both types of virus if they are both in your system. It does not go undetected, and I don’t know why you might think it would pick up one type and not the other.
You are vastly overthinking this.
This is your final post on your subscriptions.
Terri
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You’re welcome. And what you say about the difference between the IgG and western blot is extremely important as people read things online.
Terri
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1. If I caught hpv and hsv2 from the same exposure would antibody build up be slower for type 2 hsv because of hpv.
NO!
2. I would think I’d of had the classic outbreak if it was a coinfection, especially with all the trauma I put him through. With all the cryotherapy and biopsy. Would you agree.
I would agree – I don’t believe for a moment that you have HSV 2
3. After 8 months neg wb for type 2 I feel good about it and now I have answers of what the bumps was. Should I stop stressing hsv 2 now
Yes, please!
4is it true a healthy immune system can clear the hpv virus within 2 years?
It clears most often, yes, was the HPV typed? If not, it probably should have been. Certain types are more troublesome – 16 and 18. A visible wart though is almost always type 6 or 11
Is that meaning no more and not infectious to others. Or does it mean it suppresses it and can still be passed on.
It is unlikely to be passed to others, but the science of HPV is evolving all the time
Terri
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1.those that are gG deficient and never show pos on regular igG, will the western blot still pick it up from the other proteins from the immune response it looks for, 14 different ones and 4 needs to be positive I believe u said.
Yes
2. Have you ever had cases of anyone coming back positive after a negative western blot, especially taken beyond 7 months from the same exposure?
You mean positive on a swab test? Yes, 10 people in 35 years of practice were positive by swab test and negative on the blot. Some had taken substantial antiviral therapy, some not
3. Is the hsv virus slow growing in some people (maybe the ones with an established hsv1 infection) beyond 7 months and there for go undected?
No, that’s not the issue
4. Does it mean an abnormality if one takes long to test positive? What could be the reasons behind it?
Taking antivirals is a big one, other than that, we don’t know
This is your final post on this subscription.Terri
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1. Have you seen people return positive from the same exposure after say 1 year, what’s the longest that you’ve seen someone take to turn positive on igg.
I have seen people never be positive and IgG that are positive on the Western blot
The ones that don’t turn positive on igG im sure western blot will find other antibodies, right.2 also whats the longest that youve seen someone take to turn pos on the western blot after infection
I know the wb is very accurate but in some cases it missed infections but in these people theyve swabbed pos.
That is correct. I have not seen someone who has not taken medication turn positive after four months.
3. Are most the cases wb missed and later swab pos hsv1 related because it’s not as accurate as hsv2 testing
The people that I have seen to our Western blot negative but swab test positive are all HSV-2 cases.
When you say swab pos are you meaning before testing or later on eventually having outbreaks then swab posThese people had had repeated outbreaks that were swab test positive and later Western blot negative
4.Have you ever seen in your experience anyone end up having an outbreak after testing neg on wb after neg testing this far out
No
5.If wb misses a case will it continuously miss the infection like the igG? After 3 times testing do you feel like it would of caught it? Or will it miss it every time.
Have only had one person retest more than once and it was negative second time
It’s a very tough virus that the immune system does not recognize as a pathogen. Is this the reason for long seroconversion. When reading this kind of stuff it’s difficult to be 100% certain ones not infected.
We do not understand the reason for a long seroconversion but it is rare
6. by saying this are you referring about testing on the regular igG being the western blot is looking for all proteins of the immune response? Or both methods of testing
I don’t know what you’re referring to here
7. Would you feel if I was infected, the 8 month 34 week western blot would of atleast had an indeterminate result? Thanks for your time.
Yes
Thanks for your time.
I’m gonna do a final test in a few weeks. I’ll let you kno when it’s being sent. Thanks again for everything. -
1. Have you seen people return positive from the same exposure after say 1 year, what’s the longest that you’ve seen someone take to turn positive on igg.
I have seen people never be positive and IgG that are positive on the Western blot
The ones that don’t turn positive on igG im sure western blot will find other antibodies, right.2 also whats the longest that youve seen someone take to turn pos on the western blot after infection
I know the wb is very accurate but in some cases it missed infections but in these people theyve swabbed pos.
That is correct. I have not seen someone who has not taken medication turn positive after four months.
3. Are most the cases wb missed and later swab pos hsv1 related because it’s not as accurate as hsv2 testing
The people that I have seen to our Western blot negative but swab test positive are all HSV-2 cases.
When you say swab pos are you meaning before testing or later on eventually having outbreaks then swab posThese people had had repeated outbreaks that were swab test positive and later Western blot negative
4.Have you ever seen in your experience anyone end up having an outbreak after testing neg on wb after neg testing this far out
No
5.If wb misses a case will it continuously miss the infection like the igG? After 3 times testing do you feel like it would of caught it? Or will it miss it every time.
Have only had one person retest more than once and it was negative second time
It’s a very tough virus that the immune system does not recognize as a pathogen. Is this the reason for long seroconversion. When reading this kind of stuff it’s difficult to be 100% certain ones not infected.
We do not understand the reason for a long seroconversion but it is rare
6. by saying this are you referring about testing on the regular igG being the western blot is looking for all proteins of the immune response? Or both methods of testing
I don’t know what you’re referring to here
7. Would you feel if I was infected, the 8 month 34 week western blot would of atleast had an indeterminate result? Thanks for your time.
Yes
Thanks for your time.
I’m gonna do a final test in a few weeks. I’ll let you kno when it’s being sent. Thanks again for everything.
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