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In January I tested positive for HSV 2, though my husband was negative and it had been over 3 years since I was sexually intimate with anyone else. My index was 13.9. We tested because we plan on opening up our marriage. I have no history of outbreaks or reason to think I would be positive. I submitted a western blot about 4 weeks ago and received an indeterminate result. The interpretation says indeterminate can mean 1) seroconversion, exposure within last 3 months 2) indeterminate immune response or 3) remnant of receiving blood products which I have not. I do have T1D and Hashimotos so my immune system is wonky. It is very frustrating to not have a definitive answer at this point.
My question is can I say with reasonable confidence that I do not have HSV2? There is an option to submit another sample in 3 months but I have had no potential exposure in years.
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About 8% of my results are indeterminate. But if your husband has been your only partner in 3 years and you have been his only partner, then a repeat test in 3 months isn’t going to give you any greater clarity because you are not in the process of seroconversion. Most often, you have an indeterminate because you have random protein, unrelated to herpes, that is showing up on the blot. In all my years of doing the blot, I have never seen anyone go from indeterminate to positive on the second draw IF they’ve waited 12 weeks from any concerning sexual encounter to do the test AND they’ve not taken an extended course or antiviral medicine right after acquiring new herpes.
I think you can say with reasonable confidence that you don’t have HSV 2
Terri
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