February 5, 2019 at 1:09 am #30263
I’m a 22 year old female.
I have been having severe anxiety over the past year due to the uncertainty of HSV2. It has been so bad at some times that I haven’t been able to leave my house/attend university.
It all started when I had an unprotected encounter with someone I didn’t know very well. I do suffer from OCD which didn’t help my paranoia. The day after the encounter I had flu like symptoms with pains in the neck and groin. In the months that followed every now and again my vagina would feel swollen, uncomfortable and itchy. I also occasionally get nerve pains in my legs (burning sensations in my thighs and pinching pains in my labia and bottoms of my feet).
I have been to different gynaecologists about 10+ times when I feel these symptoms – nobody has seen anything herpetic apart from one doctor online who I showed a picture to and she suspected HSV2 but was unsure. I had swab test of a sore, red patch about 5 months ago, it came back negative for HSV 1 and 2. I then had a urine sample 4 months ago, negative again for both. I decided to have an IGG done privately (even though I was strongly advised not to as the NHS does not recommend anti-body testing) but I needed to know for sure! It came back NEGATIVE with index 0.500. I did a second IGG to make sure and it came back 0.520.
I wish I could accept the results but the fact that its only 92% reliable really worries me. If I were a patient in the US would you recommend I take the WB test? And is there a way UK residents can take the WB? If I payed for shipping etc. Would the blood last long enough overseas?
I’m so sorry for such a long message, thankyou so much in advance for your time. It means everything to me to get a confirmation and to final start living as normal again.
February 6, 2019 at 2:53 pm #30328
We have certainly done western blots for people who live int he UK if you can find someone to draw and spin your blood sample. I can work with you to obtain the lab requisition you need to get the test but you would need to find someone to draw and spin one serum separator tube of blood.
Do I think you need this medically? No. Do I think you need it psychologically? yes, but only if you will let it be the final word on whether you have herpes or not
February 7, 2019 at 4:18 am #30347
Thanks so much for your super speedy response! You offer a life line on here to people with concerns!
Okay! I do agree with you, I need it for the Psychological benefit of being able to confirm the negative results. It is my OCD not being able to let it go knowing there is a more reliable test out there than IGG.
Just a couple questions:
1. The more times you take the IGG and receive a negative, does this mean the more likely it is a true negative. (Therefore receiving a more reliable result than 92% accuracy when doing one test?)
2. After over one year of possible exposure, could I still be building up the antibodies that haven’t reached a detectable level yet? Or by now if I had HSV2 would it definitely be detectable after one year?
I possibly would like to go ahead with WB test but don’t have a lot of money at the moment so will wait until May when i’ll be more financially comfortable and contact you about it then. Thankyou for your patience with me!
February 7, 2019 at 7:53 am #30355
1. No, in my experience, if the test misses an infection once, the IgG will miss it multiple times. One other option is to use a different lab who uses a different brand of IgG to see if it too is negative. That would give added strength to a negative result.
2. No, not unless you have been taking antiviral therapy which would alter the test results in favor of a false negative.
When and if you are ready, let me know. We’re here to give you a hand.
February 8, 2019 at 8:43 am #30396
Thankyou for your response Terri. Just one last question from me…
1. I read that with the ELISA test, 92% of positive results are correct and 98% of negative results are correct.
And then with Western Blot 94% positive results are correct and 99% of negative results are correct.
Do you agree with this? Therefore the western blot would only be 1% more accurate in giving me a true negative?
2. Does a low negative index number mean it more likely to be a true negative than a higer negative index number?
Thanks again for your patience and advice!
February 14, 2019 at 3:30 pm #30580
The western blot picks up 99.9% of HSV 2 and 95-96% of HSV 1
Yes, I think the low negative can be more accurate than a high positive, particularly for HSV 1 and with someone who is concerned about having a new infection with a high negative.
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- This reply was modified 6 months, 1 week ago by Terri Warren.
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