low igg/western blot

[iggconfused]

Hi Terri-
I have always reported a negative hsv igg and igm every year I have been tested. This last test they only did the igg as I understand they did away with the igm. Last year I received a negative igg and igm (january/21), though I had two partners within the few weeks leading up to that test. Since that negative test I then have had 2 additional partners and had my latest physical march/2022. For my last physical, my igg results was igg positive hsv 2 (1.1), with supplemental reflex test positive (both labcorp). I was very distressed by this and had another test 5 days later (though they said I should wait). My result was igg positive hsv2 (1.25), with supplemental reflex test positive (both labcorp). All tests were hsv 1 negative. I have never had any clinical symptoms suggesting infection or if I was not sure a doctor confirming was not infection. In 2020, I did contract Molluscum Contagiosum in 2020 on my stomach area. It was swabbed and negative for hsv 1 or 2 and was treated and disappeared.
The only notable difference this year from previous years I can think of is I received both covid vacines and the booster. Not sure if the covid vaccines might have bumped up my igg test a bit from previous years?
I have talked to several internists and trusted friends and they have advised me to move on. This coupled with the statistic I read from you that low readings such as mine are about 85% false positives.
I wanted to get your advice as to going through the process of the western blot to confirm. I would need to wait another two months so it is 3 months since the last time I had sex with my last partner and not plan to engage in any contact in the interim. I am not sure if going through this process will make me feel better or not. Those close to me have told me to move on as where I am now is not a bad place (no symptoms, and results arguably within the margin of error) but I am torn.
(also note have always used condoms)
Thank you.

[Terri Warren]

You are absolutely on the right track to get a western blot. The supplemental test at LabCorp, in my opinion, is being overread. I am actually presenting a paper about that at a meeting later this month. Please do not believe the supplemental test at this point. I think there is an excellent chance that your western blot will be negative since you have such a low positive IgG result. You are wise to wait the appropriate amount of time to do the test and if you need my help ordering it, I am definitely here for you

Terri

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