February 20, 2019 at 7:33 am #30817
My now ex slept with someone else and didn’t tell me. He went in 18 days later and got an STD test. It came back for hsv2 positive. That was in September. I went in and had a negative igg for hsv2 that week. I had a soar which isn’t unusual for me bc I have behcets. I had them swab it using pcr and it came back positive for hsv2. The next month I had an eqivical hsv2 blood test at .97. He went in 6 weeks after his original test and had a negative test, so his doctors cleared him. I started valtrex in October. I had a negative igm in November. Went in Dec 17 and was tested for hsv2 by igm and igg, both test were negative. That was processed through the Mayo clinic. I stopped the medicine and went back Jan 2 and had the herpeselct2 igg done which was also negative. I started the valtrex back up bc I got scared and went in for another hsv2 igm and igg on Jan 23. Both of those came back negative. That was 18 weeks after the positive swab. About 7 of those weeks I wasn’t taking valtrex. All the doctors I’ve spoken with said even with taking valtrex I should of tested positive by 18 weeks and that valtrex can not make an equivalent test change to negative. I’ve been off the valtrex for 2 weeks and I’m going in another week for another igg test which would be 23 weeks. Do you think I could of had a false positive swab? Can valtrex make a equvilant test change to negative? If you are taking valtrex would you still not test positive by igg after 18 weeks past exposure (even though 7 of those weeks were not medicated)? And if I have to be off of valtrex for 12 weeks for accurate results.. is that 12 weeks all together or 12 weeks in a row? My ob, my reg doctor, my work nurse have all cleared me. I also talked to the health department and HIV specialist, all of which said I don’t have hsv2 bc it would of show up by 18 weeks even on valtrex. Do I need to retest again after the 6 month mark?
February 20, 2019 at 12:12 pm #30836
Cleared you? You mean told you that you don’t have HSV 2 because your antibody test is negative? I could not disagree more strongly. A positive AND typed LESION swab far overrules an antibody test. With no antiviral medicine, the IgG test misses 8% of HSV 2 infections. WITH medicine, it could certainly miss more. The most accurate test is the herpes western blot. If you stayed off medicine for 12 weeks in a row and tested with the blot, I am quite certain you would test positive for HSV 2 antibody. As for your partner, he had an IgG that was positive, is that right? Do you know the number associated with his positive I don’t believe the Mayo clinic gives index values (which is in opposition to the CDC who says people with index values between 1.1 and 3.5 need confirmatory tests – how can you know if you aren’t getting the index values.
Negative and equivocal values are VERY close together so .07 is so close to negative – it doesn’t matter. And the swab outweighs this.
The University of Washington is VERY clear that antiviral therapy can interfere with an antibody test. If the medicine is working well, the virus cannot replicated and in that case, the immune system cannot see it and make an immune response called antibody. Seems pretty simple to me
February 20, 2019 at 1:26 pm #30840
Yes they all cleared me as in saying I do not have hsv2. I did not have hsv2 prior to being with my ex. I get tested after every relationship and he was the only guy I was with for the last 2 years. His original test just said positive. When they retested him by blood and urine 6 weeks later both test came back negative. All my doctor’s said the positive swab must have been a false positive because at 18 weeks I should have antibodies regardless of taking the valtrex.They said even though false positive swabs are rare that they still happen. Even when I stopped the valtrex for a few weeks and got retested I was still negative. The lady who did the swab said it didn’t look like a herpes soar and looked more like a behcets soar. If my ex doesn’t have herpes then there is no way I could have it. Do you think I should stay off the medicine for 12 weeks and do the western blot? I’ve asked all the doctors about the valtrex bc I read where you said it effects testing and they all told me with 7 weeks of not being on it I would still test positive. Should I just assume that I have it or should I do a western blot just in case?
February 23, 2019 at 2:33 pm #30949
You could come off medication for 12 weeks and if you have an outbreak, have it swab tested again, or if no outbreak, do the western blot
BTW Bechets sores and herpes sores look just the same.
While false positives can happen (I have seen two in 35 years of practice), they are far rarer than a false negative on the IgG test.
I had a patient who was swab test positive but when on suppression immediately with first infection. 9 months down the road, she did an antibody test and it was negative for HSV 2. I pulled her off suppression and she tested positive on the antibody test within one month. The University of Washington states the same.
I think you need to decide that you are going to believe one source of information or another but bouncing between sources isn’t useful or productive for you.
June 16, 2019 at 12:23 pm #38325
Update.. I went off of the valtrex and retested at 2 weeks off and was still negative. I went back in at 8 weeks off of it and had a low positive at 1.13. went back in at 11 weeks and was positive at 1.55. I’m at 16 weeks out now and still haven’t had any soars. I started taking the valtrex again 2 nights ago bc I was having ear pains and I’m not sure if I have it orally as well. Can it cause ear pain? What are your thoughts on Gene editing creating a cure? Do you think this will happen anytime soon? I read they are in the middle of a vaccine that will use a prime and pull method. They are also research using the doctor who did off shore trials who later died of cancer to help people who have soars, but this doesn’t sound like a cure just an alternative to other medication. How far off do you think we are from using crispr case 3 to put an end to this disease? I’m terrified of spreading it to other areas of my body while on immune suppresants.
June 20, 2019 at 7:34 am #38688
Genital herpes does not cause ear pain, no. You are likely having low positives because of taking the Valtrex. Your physicians are uninformed about the impact of Valtrex on antibody testing.
Why are you on immunosuppressants?
Your doctor is talking about Rational Vaccines. It got off to a very rough start but is coming back with a more ethical and careful plan now. We’ll see.
I don’t know the timing of CRISPR
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