February 9, 2016 at 6:46 pm #11903Relieved (Hopefully) in CTParticipant
First I want to thank you for having this outlet for all of us to pose these questions to you. It is a tremendous resource!
I will try to give the facts similar to other posts
1) Long term Gay relationship with my husband of 16 years. Found out an affair and we are in process of divorce. Due to affair I had a full STD screening done all test negative except for below. I have not had sex in almost a year can’t pinpoint the exact date but certainly more than the 4 months you have asked of another poster on the forum
1) Tested 1-18-16
a) HSV-1 IgG Antibody negative (Value=0.11)
b) HSV-2 IgG Antibody positive (Value=3.27)
2) Same Sample follow up testing via HSV-2 IGG Inhibition Study result was positive on 1-19-16. Report notes: “This assay is intended only for samples giving a positive index in the HerpesSelect HSV-2 type-specific IgG screening ELISA. A POSITIVE inhibition study interpretation indicates true HSV-2 specific reactivity.”
3) Follow-up research said get Western Blot which I did 2-3-16. Greta news, results were Negative!! stated as: ” Negative for antibody to HSV-1 an HSV-2 by Western Blot. No evidence of past infection with HSV-1 or HSV-2.
1) Is the Western Blot conclusive? All research says yes and I hope I can stop here.
2) My doctor’s practices (not helpful at all) reminded me that this was not an FDA approved test which is noted on the UW test result report ” This test was developed and its performance characteristics determined by UW medicine. It has not been cleared or approved by the U.S Food and Drug Administration.”
Should I be concerned? Everything I have read says Western Blot is the Gold Standard.
3) Hopefully the answer to #1 is yes I am at the end of this mind numbing journey and i am negative However when I find me new partner and should he ask for me to be tested in the future, will I always get a false positive in HSV-2 test?
February 11, 2016 at 9:01 am #11916Terri WarrenKeymaster
Yes, the western blot is considered the gold standard antibody test. It is not an FDA approved test because they have not submitted it for FDA approval – no need to – this is not a test that is going to be widely used because it takes 3 highly trained readers to assess each test. FDA approval is normally requested when a test is going to major labs. It might also be useful to know that a positive western blot is the usual entry criteria into any clinical trial of a new medication, vaccine, etc.
In my experience, once a person has a false positive ELISA, they always do, or most always do.
I think you’re good to go but remember to practice safer sex to protect this negative status (not to mention your HIV status and other STI’s.
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