June 26, 2019 at 4:00 pm #39238
Hey Terri, thank you so much for what you do. Here’s my situation:
- Had unprotected oral and vaginal sex with a friend of a friend. This was my Last Possible Exposure (LPE).
- Flu-like symptoms appear roughly 10 days later, I assume I have the flu.
- Go in for annual physical including Herpes blood test. This is 4 weeks since LPE.
- Results come back as POSITIVE for HSV-1 and HSV-2. Test was an IgG. Index values for both were “Greater than 5.0.”
- Other than the flu-like episode in late March, I have no symptoms at all. No sores on mouth or genitals, nothing to swab. Diagnosis is based solely on this blood test.
- Dr. prescribes 1g Valacyclovir to be taken daily as a suppressant. I go on it immediately, never miss a dose.
- After doing research and discovering Herpes tests are notoriously flaky and unreliable, I decide to do a confirmation IgG type-specific test at a totally different facility and lab. This is 8 weeks from LPE and within 10 days of starting Valacyclovir.
- Results come back as NEGATIVE for HSV-1 and HSV-2. “Less than 0.90” for both types.
- I continue to take Valacyclovir 1g daily, unsure about my status, resolve to test again in 4 more weeks.
- I do yet another confirmation IgG type-specific test at a totally different facility and lab. This is 12 weeks from LPE.
- Results come back as NEGATIVE for HSV-1 and HSV-2. “Less than 0.90” for both HSV-1 and HSV-2.
- At this point I begin to believe I may not have Herpes. I stop taking Valacyclovir and resolve to test again in July, which would be 16 weeks past LPE.
- Still asymptomatic.
Can you help me sort out what to make of this, what to do next, and when I can be confident of my status, either way? Was this a false positive, or was Valacyclovir giving me false negatives?
June 26, 2019 at 10:01 pm #39553
This is very disconcerting. Both for you (primarily) and me as well.
I suspect there was some confusion with your sample and someone else’s sample with the first sample. A value of >5 is not new infection. Let me ask you – were your tests all done at the same lab?
June 27, 2019 at 5:23 am #39596
The positive test in April was done at Quest Diagnostics. The tests in May and June were done at LabCorp in two different cities. Each time in 2019 my blood has been drawn at a separate, distinct facility.
Some additional context, if it helps:
- I previously had this same physical done at the same doctor’s office back in September. Was negative for HSV-1 and HSV-2 then.
- Possibly related to your thought on them confusing my sample: With the results in April my doctor said my cholesterol had jumped the highest he had ever seen it, in a difference he did not think was humanly possible, between that last physical in September and this one in April.
- My other previous LPE would have been with my ex just before we broke up in October. No other sexual activity between these two events in October and March.
June 28, 2019 at 8:04 am #39688
Perhaps more evidence for confusion of the sample, hmmmmm.
You may wish to consider a western blot though I would GUESS that it would be negative. For some, this confusion would not be tolerable and clarification would be important. Others might be able to accept that this is likely an error. Your call.
June 28, 2019 at 5:29 pm #39724
Thanks again Terri. I believe this is my last post on this session.
If I take one last IgG in July, that would be 16 weeks past LPE and 4 weeks off of Valacyclovir. If that result is negative as well, in your opinion can I put this whole matter to rest and be done with it?
July 4, 2019 at 2:59 pm #40737
Well, yes, considering the limitations of the IgG test. Compared to the western blot, the IgG test misses 30% of HSV 1 and 8% of HSV 2. So if you are OK with those statistics, then move on.
This is your final post on this subscription. If you have more questions, feel free to renew.
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