Actually, the issue is sensitivity not specificity with the HSV 1 IgG test.
1. Would repeating IgG tests for HSV-1 improve the accuracy of the result? Meaning, if I consistently get negative index value for IgG tests, does that mean that I’m true negative for HSV-1? i.e. does it improves its accuracy?
Not really. I have seen people test multiple times and miss it multiple times.
2. Assuming that I am HSV-1 positive, if I receive a false negative from my tests, would repeating IgG tests continue to give me a false negative?
see the answer to 1 – yes, likely, it would
3. The reason I am asking question 2 is I have read in some forums saying that this is the case. If this is the case, why is that so? What is the reason behind it?
The issue is the sensitivity of the test, not something about the person. And these values are compared to the gold standard western blot. The blot picks up 30% more HSV 1 infections than the IgG test and 8% more HSV 2 infection than the IgG test.
I don’t know why, in an individual, it would miss an infection multiple times.
Also, I would like to note that I did not experience any outbreak up until now. I do get itches and rashes from time to time, but none have developed into a full fledge outbreak. However, these random itches and rashes makes me anxious and unable to move on. That’s the reason why I am trying to find out if repeating the tests help improve its accuracy. I do not stay in the US so Western Blot is kinda out of the question.