I have had two patients who began taking antiviral medication daily during their first outbreak with HSV 2. One had not made antibody detectable by western blot 9 months later, a second had taken antiviral medicine daily since a new infection 2 years prior and her IgG was negative – she didn’t do a western blot but did come off antivirals and was positive a month later.
The University of Washington does warn that antivirals taken early and daily can impact the accuracy of the western blot. If the antiviral medicine is working well, the virus is not reproduced and therefore the immune system cannot see the virus and will not make an antibody response, even the western blot cannot detect.
I’m glad you were able to sort this out
Terri