Reply To: Next Steps: HSV2 IgG low positive with two negative supplemental tests

[cmr892]

My tests did come back positive for Trichomoniasis, which I was given Metronidazole for. I was also given an antiviral medicine due to the PA at urgent care not trusting the validity of the PCR done on the lesion. I was encouraged to make a follow up appointment with my PCP, which I did 2 weeks later, 7 days after stopping the antiviral [I did complete the entire prescription given]. My PCP did a full STD panel and the results were the following: HCV antibody NEGATIVE, RPR NON-REACTIVE, Hep B NEGATIVE, HSV1 2.35 and HSV2 .94 EQUIVICAL and a NEGATIVE supplemental. I was instructed to take another test 4 weeks later for the HSV2 for confirmation testing, those results were 2.82 with a NEGATIVE supplemental test. The dates for the two sets of tests were 2/10/2022 then 3/10/2022. More information about the tests used 2/10/2022 HSV Type 1 IgG [result 2.35] and HSV-2 Type Spec Ab, IgG w/Rflx 163033-LC [result .94 with negative supplemental] then 3/10/2022 was just HSV-2 Type Spec Ab, IgG w/Rflx 163033-LC [result 2.82 with negative supplemental]. I have not spoke my PCP about the new test results yet, I just saw them 3/15/2022. Before the second test we discussed if it was equivocal again with a negative supplemental we would agree that it was negative. However, because the value increase so much, it really freaked me out and I’m not sure what I should think. I’m considering doing the Western Blot test for peace of mind and based on what I’ve read in the forum, it’s probably going to be what you recommend, but I just wanted to reach out to hear from an expert on what you thought about the dramatic increase of the HSV2 value. I should also note, one of my sexual partners, who I had relations with around the time I got the vaginal lesion got his HSV 1 and 2 results back as 45.5 HSV1 and .90 HSV2. Thank you for your help and please let me know if you have any questions about the situation.