Curious on the methodology of IGG tests. Many people quote yourself saying the tests ‘miss about 30% of HSV1 cases.’ Figure 1 of this article also concurs to that statement, noting the HerpeSelect test at 12 weeks/3 months had 73% or patients having seroconverted (trending to 78% at 6mo).
1) Does this mean the case is not detectable or it was not detected? I.e. if another test was done the day after, is there a fair possibility of it picking up the infection, or is it forever ‘undetectable’ per the percentages noted in the article above and as referenced by yourself?
Is it a certain ‘strain’ that is undetectable? I.e. if HSV1 was not detected in one person, would it be detectable in someone else assuming it transmitted between the two individuals?
2) What are some stats/data on patients never developing antibodies or never testing positive on IGG for HSV1 and 2?
3) If one were to have a possible history of cold sores, would those antibodies protect from the GHSV1?