I would say it is difficult to sort out the irritability due to having herpes vs. from the medication. People take acyclovir due to having HSV 1 or 2, most often. Some people may take this for shingles as well. I personally have not seen this problem with my patients. YOu could always try it and see how it goes for you. This isn’t like an antibiotic that you need to finish totally to be safe and effective. You can take it and then stop if it bothers you in some way.