Reply To: IgG accuracy / IgM question

[stressmachine5000]

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2. I’m curious about the 30% false negative with HSV1. Low positive index values are a significant predictor of discordant results between Elisa and WB. Does the same concept apply to high negatives with an HSV1 test? In other words, assuming all other factors (lab, timing, lack of symptoms, etc) were the same, would you expect a person with an HSV1 IGG of 0.1 to share the same 30% chance of a false negative as someone with an HSV1 IGG of 0.7?

3. We are in Europe. The WB is out of price-range, and doesn’t seem reasonable in my case. But, I do still worry about that 30% false-neg for HSV1. After 3 months of stress, I don’t want to give her GHSV1 thanks to a false test. Would you feel confident in a negative result if we both tested negative after 3 months with each other? Especially as my most likely time of transmission has already passed and we weren’t using protection?

4. HSV2 increases your risk for HIV. Is the same true with GHSV1?

5. Your research was compared to American ESLIA tests, whereas in Spain we are using CLIA. Though similar in procedure, the research that I have found suggests that CLIA is be more sensitive. Do you have any knowledge of this?

6. My doctor seemed to believe that the IgM was likely a false pos caused by the full body rash (urticaria) three weeks prior. I have had full body hives before due to allergy, though in this instance there was no obvious allergen to explain it. This rash did not cause any ulceration, the only lasting effect was constant peeling of the fingertips for 2 to 3 weeks afterwards. Very strange.
Have you seen IgM positives be skewed by other factors such as this? More importantly, in all your years have you ever seen anyone whose first symptom (or any symptom) of HSV be full body hives?

Thank you, Thank you, Thank you, from me and all of us!