Reply To: Hsv-2 IgG 4.2, Supplement positive. False or Double test?

[Terri Warren]

The supplemental test can certainly be a false positive – I now have 112 patients with this situation.
The western blot “weighs” the antibodies, sort of
If you want to be really certain about your status, I do recommend the western blot yes. it is considered the gold standard of herpes antibody testing.

Terri