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Reply To: Igg and supplemental test results

› Forums › Herpes Questions › Igg and supplemental test results › Reply To: Igg and supplemental test results

April 20, 2023 at 8:57 am #81354
Terri Warren
Keymaster

I would strongly disagree with your doctor’s opinion on this. People who have a high HSV-1 index value fairly often have some cross-reactivity with HSV-2, causing a low positive HSV-2 IgG. I have been collecting data on patients with LabCorp testing done with the supplemental test. We now have around 40 people with a negative supplemental test from LabCorp who also had negative Western blots. We have poor agreement between people who have positive IgG results and positive supplementals. We have over 120 of those who are negative by Western blot. I don’t really understand why your doctor would say if the supplemental test is negative that, you are still infected from your first testing. Also, there is really no reason to repeat the test at a given time unless you’ve had a new sexual contact and are possibly making antibodies from a brand-new infection.

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