I don’t think we have any actual evidence about this 1) because it hasn’t been studied carefully and 2) the IgG test already misses 30% of HSV 1 and 8% of HSV 2, without any antiviral meds at all, or 3) if there might have been a new infection going on, the timing, not the drug could yield a false negative.
I have had patients who were on longer doses of suppression who did not develop antibodies until we pulled them off suppression. One as long as two years on suppression with no antibody response pulled her off and in 6 weeks she was antibody positive (prior positive swab test).
If this is a legal issue for you, the igG test is not the definitive one to rely upon.
Terri