Thanks, but it’s the opposite of what you say.
The initial IgG test was (low) positive (using a CLIA assay), then the follow-up confirmatory test (Labcorp membrane assay) was negative. From my original post:
At 3 months, I got the Labcorp IgG w/ reflex test. Results were:
IgG: 1.17, HSV2 reflex test negative.
You’re saying that the membrane test has a high false positive rate, but in my case the question is what is its false negative rate, which presumably would be different. Does that change your opinion at all?
In any case, I’ll look into getting a western blot ordered since it would be nice to have an unambiguous answer. Thanks again.
Hah, I was hoping you’d say “yeah definitely a false positive!”
So a few follow-up questions:
When you say “a good confirmatory test,” does that imply the Labcorp reflex test (membrane based immunoassay) is not a good confirmatory test? I realize the Western blot is the gold standard, but for an ambiguous case like this, is that the only method you’d recommend?
Do you have any suggestions for how to get a Western blot in the San Francisco area?
My doctor seems to imply that “less IgG antibodies” => “less active (or inactive) viral infection” => “less chance of being contagious” which doesn’t entirely make sense to me based on my understanding of how antibodies works. Is he correct here?