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Hello again Terri,
I ask the following question above:
“A portion of the HSV Western Blot interpretation reads as follows, “… in less than 1% of cases, seroconversion may take greater than 12 months…” …. Does this mean that I still have about a 1% chance of being HSV2 positive at this point? Will I ever be able to unequivocally say that I am HSV2 negative?”
And you responded with:
“It’s way less than 1%.”
My questions are:
(1a) How do you know that this is the case? How can you say this with certainty?
(1b) Where is the data you are basing this statement on? Can I please see this data? Could you link me to the relevant scientific literature? (I assume there must be some data on the percentage of a population that was exposed to HSV and has undergone seroconversion according to the Western Blot test as a function of time).
What does it mean for a paired serology to have been performed? What is is the process and how does it differ from just having a regular Western Blot test performed? Why is a paired serology used and what additional information does it provide that a regular Western Blot test does not provide?
If I was willing to spend any amount of money to perform other tests in order to confirm whether or not I have HSV2 are there any other such tests? For example, if I do have HSV2 I should at some point over the course of a 30 – 60 day period (or more?) shed the virus and therefore if I where to swab my genitals and buttocks region for that period of time and then have PCR tests performed on those swabs would that be a more thorough way of testing than the Western Blot?
1) A portion of the HSV Western Blot interpretation reads as follows, “… in less than 1% of cases, seroconversion may take greater than 12 months…” …. Does this mean that I still have about a 1% chance of being HSV2 positive at this point? Will I ever be able to unequivocally say that I am HSV2 negative?
2) Would you recommend me completing the Western Blot test again at 12+ months since the last time that I had sex? If yes, how many months should I wait?
3) Are there any other tests that I could perform and that you would recommend given my situation, that would help to provide further clarity on my HSV2 status?
4) Assuming that you agree with UW and discourage any further testing, would you recommend that I inform any future partners about my HSV2 status? I feel like I am obligated to inform any partners that I may have of the situation because it seems to me that there is a big difference between 2 indeterminate WB results and a negative WB result.
According to my parents, both sides of my family have been U.S. citizens for at least 3 generations, thus at the very least I am a 4th generation U.S. citizens … I am really curious as to how this information relates to my HSV2 status?
This is the first time that I have heard this interpretation of my results. According to the doctor/representative at UW Virology whom my doctor spoke to about my results (UW is not allowing patients to discuss their results with UW doctors anymore because of COVID), she said that I should interpret 2 indeterminate tests as me being negative and actually discouraged further testing … this really didn’t make sense to me … would you recommend that I do not have sex for a year and redo the Western Blot to get a definitive result? I am more than willing to do this. I want clarity on this so badly.
My results seem extraordinarily improbable. Would I be useful to anyone in helping to make these HSV2 tests more accurate or useful in some other way? My test results seem so contradictory and extreme that I figured someone may be interested in using me to learn more about herpes.
Are my current and persistent symptoms (inflammation and irritation of urethra, inflammation and irritation of the anus / tailbone area, and no pain during ejaculation but 10 – 20 mins after ejaculation my urethra becomes noticeably aggravated.) indicative of HSV2 or not? What would you recommend that I do to address them ( I have no STIs and am currently attempting to get a referral to a urologist and proctologist)?
How does the Western Blot test work? I am struggling to find education materials on the mechanics of the Western Blot test that UW employs. Any references you could share?
6) What does an indeterminate result on the WB test mean? What differentiates it from a positive or negative result? How can I get more insight into what my actual test results are say, instead of just receiving 1 of 3 words (neg,pos,indeterminate)?